Moore worked two seasons at the Oregon Shakespeare Festival prior to moving to Los Angeles. In 2004, he appeared in the Vince Vaughn-Ben Stiller comedy, Dodgeball. His recent films include Art School Confidential (2006) Spiral (2007), Shanghai Kiss (2007), The Hottie & the Nottie (2008), Weiners (2008) and the upcoming James Cameron film Avatar.
In 2007, Moore and Adam Green received the Gold Vision Award at the Santa Barbara International Film Festival for Spiral. He was the executive producer, co-director and co-writer of the film. He was also nominated with the rest of the Dodgeball cast for the Best On-Screen Team at the MTV Movie Awards.
Moore directed the short film Miles from Home in 2006.
He has appeared in episodes of Boston Public, Boomtown, Providence, Sabrina the Teenage Witch, Angel, LAX, CSI: Crime Scene Investigation, E-Ring, and House M.D.